Artificial Intelligence (AI) is revolutionizing many aspects of human activities thanks to recent advances in technology and boost to computing power, and the availability of data on which AI models depend for training. Over the last few years, the potential of AI in Medicine has become clear with the successful development of many applications, from enabling new insights into etiology of disease and pattern recognition in large biomedical datasets, to facilitating new paths to drug discovery and improving health monitoring and management through AI-supported diagnostics and treatment decision making tools. This decade promises ever more insights into the mechanisms of diseases facilitated by big data and machine learning and to bring more of these technologies to the clinic.